(2) Greater SGLT-1 expression in CF female mice: Genistein’s remarkable effect on SGLT-1 expression in females is perhaps not surprising; regulation of SGLT-1 expression by protein kinase A (PKA) and protein kinase C (PKC) has been demonstrated in intestinal tissue [53] and Epidermal Growth Factor has been shown to have stimulatory effects on PKC-regulated glucose absorption [54]. This evidence concerns the gene PRRT2 and cystic fibrosis.