Several tumor suppression genes (e.g., TP53 and CDKN1A), Ki67 proliferation index, and markers of angiogenesis (e.g., microvessel density and thrombospondin-1) have been found to predict tumor recurrence and survival, as confirmed by the preliminary data of ongoing clinical trials [18,19,20,21,22,23,24,25,26,27,28]. The gene discussed is THBS1; the disease is neoplasm.