Other immunohistochemical markers such as MMP7, Endoglin, Beta-catenin, PPRG, GADD45B, and MET are associated with the development of liver metastases and give only indirect prognostic information, given the fact that patients with the metastatic disease show a worse 5-year survival than nonmetastatic counterparts. This evidence concerns the gene MET and metastatic neoplasm.