qtRT-PCR technology and siRNA-mediated knockdown and adenoviral delivery-mediated overexpression of EMX2 were performed showing that colorectal tumor samples had decreased EMX2 expression levels, and its downregulation was associated with distant metastasis concluding that overexpression of EMX2 led to an inhibition of tumor cell migration [57]. This evidence concerns the gene EMX2 and colorectal neoplasm.