While we did not observe enhanced inflammation (i.e., increased Tnf, Saa3, or Ccl2) in aortic or PVAT tissue from mice supplemented with 10,12 CLA, nor in macrophages treated with IL-4, whether the observed increase in IL-4 is causally associated with improved atherosclerosis in these mice remains to be explored. Here, IL4 is linked to atherosclerosis.