As we have previously shown that 10,12 CLA supplementation promotes the browning and M2 macrophage enrichment of white adipose tissue [4], and we now show that PVAT in these mice expresses elevated levels of irisin and the M2 markers Egr2 and Mrc1, it is plausible that M2 macrophage-containing PVAT secretes factors that promote atherosclerosis regression. Here, FNDC5 is linked to atherosclerosis.