In our previous study, we reported that 14 adipocyte genes (Ccl7, Emr1, Evi2a, Gusb, H2-DMb2, Lcp1, LOC100041137, Ly9, Ptpre, Rgs1, sc1000528.1_16, Sirpa, Sfrp5, and Acacb) were associated with both advanced age and diet-induced obesity. Here, ACACB is linked to obesity due to melanocortin 4 receptor deficiency.