5, 8, 9, 13, and 14) exhibited a decrease in Ki-67 positivity in both total and nivolumab-bound IgG4+ CD8 T cells at the time of PD or tumor marker re-elevation (Figure 5, A and B), the percentage of Ki-67+ T cells in 3 cases (Pt. The gene discussed is CD8A; the disease is neoplasm.