Receptor-mediated virus internalization via activation of the PI3K/Akt signaling pathway has been reported for the infections caused by many viruses, such as hepatitis C virus (HCV) (10), exogenous avian leukosis virus (ALV) (11), African swine fever virus (ASFV) (12), vaccinia virus (13), herpes simplex virus type 1 (HSV-1) (14, 15), porcine reproductive and respiratory syndrome virus (PRRSV) (16), Ebola virus (17), and adeno-associated virus type 2 (AAV-2) (18). The gene discussed is AKT1; the disease is infection.