First, we compared the protein levels of HO-1, SOD1, GPx4, CAT, NQO1, and actin in the combined tissues of hippocampus and cortex between 12-month-old WT mice (n = 6) and 12-month-old 3xTg-AD mice (n = 6) (Fig. S2). This evidence concerns the gene HMOX1 and Alzheimer disease.