Average band density (mean ± S.E.)was as follows: PSD95, 26,589.0 ± 945.5 for WT versus 17,887.3 ± 1677.9 for vehicle-treated 3xTg-AD, p < 0.01; GAP43, 11,491.9 ± 1757.7 for WT versus 5778.85 ± 1255.63 for vehicle-treated 3xTg-AD, p < 0.01. This evidence concerns the gene GAP43 and Alzheimer disease.