HMOX1 and Alzheimer disease: Both HO-1 and SOD1 were significantly increased in 3xTg-AD mice treated with mini-GAGR compared with those with vehicle (Fig. 8, C–E) (band density: HO-1, 4358.8 ± 538.7 for vehicle versus 10,020.3 ± 2154.3 for mini-GAGR; SOD1, 16,596.53 ± 1955.6 for vehicle versus 21,511.5 ± 521.9 for mini-GAGR).