NFE2L2 and Alzheimer disease: Similarly, the number of p-Nrf2–positive neurons in the CA1–CA3 region was higher in mini-GAGR–treated 3xTg-AD mice compared with those with vehicle (-fold changes, 1 ± 0.18 for control versus 2.64 ± 0.16 for mini-GAGR, p < 0.001) (Fig. 9J).