MAPT and Alzheimer disease: The result showed that the protein levels of p-tau were significantly reduced in mini-GAGR–treated 3xTg-AD mice compared with those in vehicle-treated 3xTg-AD mice (control), whereas those of total tau were not changed (band density: tau, 63,221.4 ± 821.3 for control versus 62,801.2 ± 3241.2 for mini-GAGR; p-tau, 18,048.1 ± 2213.3 for vehicle versus 8864.1 ± 1480.3 for mini-GAGR, p < 0.01) (Fig. 10, B–D).