SOD1 and Alzheimer disease: SOD1 and GPx4 showed a trend of decrease in protein levels in 3xTg-AD mice compared with WT (SOD1, 14,800.9 ± 1070.9 for WT versus 12,233.9 ± 625.3 for 3xTg-AD mice, p = 0.065; GPx4, 23,992.3 ± 833.4 for WT versus 19,172.9 ± 2230.5 for 3xTg-AD mice, p = 0.071).