HMOX1 and Alzheimer disease: HO-1 and CAT showed statistically significant decreases in protein levels in 3xTg-AD mice compared with WT (band density: HO-1, 6756.4 ± 681.5 for WT versus 5024.7 ± 311.5 for 3xTg-AD mice, p < 0.05; CAT, 25,388.8 ± 334.4 for WT versus 17,900.2 ± 1379.4 for 3xTg-AD mice, p < 0.001).