After examination of the WT mice compared with the 3xTg-AD mice, it was evident that the significant decreases in antioxidant enzymes, catalase (Fig. S2E) and HO-1 (Fig. S2B), and the trending decreases (SOD, p = 0.065; GPx, p = 0.071) appeared to be transgenic-dependent. This evidence concerns the gene HMOX1 and Alzheimer disease.