The p-Nrf2 intensity of hippocampal neurons in WT mice was higher than that of vehicle-treated 3xTg-AD mice (Fig. S3, C and D) (p-Nrf2 intensity in CA (1.62 ± 0.10-fold higher than vehicle (1.17 ± 0.08), n = 14, p = 0.006) as well as in DG (1.49 ± 0.10-fold higher than vehicle (1.01 ± 0.05), n = 14, p < 0.001) (Fig. S3D). Here, NFE2L2 is linked to Alzheimer disease.