Very many other AβPP fragments and derivatives are also likely to be involved in AD progression, however, such as soluble AβPP α and β (sAβPPα and sAβPPβ), C83, C99, P3, amyloid precursor protein intracellular domain (AICD), N3-pyroglutamate [2], isoaspartyl, phosphoserine and other post-translational modifications, and Aβ extended at both N- and C-termini [3, 4]. Here, APP is linked to Alzheimer disease.