Multiple stresses, such as an ApoE4 genotype [103], age, inefficient protein degradation [104], autophagic/lysosomal dysfunction [105], iron dysregulation [27], deficiencies in blood coagulation via bacterial lipopolysaccharides [106, 107], vascular conditions [108], mitochondrial dysfunction [17], viral infection [109–111], microbial infection [112], and head injury [113], are almost certainly required to initiate progress into AD. This evidence concerns the gene APOE and Alzheimer disease.