PITX2 and breast cancer: However, given that there is no good correlation between the degree of b-wave slowing and structural changes (e.g., loss of RGS or GPR179 severely compromises depolarizing response generation of ON-BC with intact morphology) amid normal molecular architecture of the synaptic cleft (intact TRPM1 and transsynaptic mGluR6-ELFN1 assembly), we think that such changes may play a secondary role in influencing the kinetics of depolarizing response to light and rather affect other aspects of the synaptic transmission.