Strikingly, we observed a significant reduction in synaptic accumulation of both GPR179 and RGS11 at the dendritic tips of EYFP-positive ON-BC expressing ecto-GPR179 (Figures 5G and 5H), further supporting a critical role of Pikachurin binding in the localization of GPR179 complex. The gene discussed is GPR179; the disease is breast cancer.