In a study of 18 women with TS and aortic dissection, 6 cases were available for biochemical analysis, and that study showed a skewed ratio of collagen I to collagen III (normally 30:70%) with 60% collagen I and only 30% collagen III,[29] which could well be the end result of an altered MMP/TIMP activity. Here, TIMP1 is linked to Aortic dissection.