Alternative splicing affects both the replication domain (RD) and NM anchor domain (AD) of CIZ1, and several splicing events have been implicated in cancer, including mutation driven exclusion of exon 4 (CIZ1-Δ4) in Ewing’s Tumor cell lines [2] and exclusion of 24 nucleotides of exon 14 in lung cancer (CIZ1-B) [5]. The gene discussed is CIZ1; the disease is lung cancer.