Previous reports have shown overexpression of CIZ1 in colon [29,30], gallbladder [21], lung [31], and prostate cancer [32], as well as ependymomas, gliomas, and medulloblastomas [33], and it has also been reported that CIZ1 knockout mice develop leukaemias and lymphomas [9,34]. This evidence concerns the gene CIZ1 and central nervous system cancer.