CIZ1 and early-onset autosomal dominant Alzheimer disease: In the same MCF-7 cell populations we observed additional effects on CIZ1 alternative splicing, most notably increased CIZ1-S (Supplementary Figure 3(a)) an isoform reported to be upregulated in Alzheimer’s disease (Supplementary Table 1), and changes in CIZ1-Δ4 (Supplementary Figure 3(b)) [2,3].