ZEB1 and aneurysm: In TAV, however, ZEB1 expression did not significantly shift in aneurysm (comparing TAV‐ND vs. TAV‐D), whilst ZEB2 expression increased as a result of aneurysm development (P = 0.0002; Fig. 3c), indicating (i) ZEB1 is not activated in TAV either before or after aneurysm development, (ii) ZEB2 activation is a postaneurysm event in TAV.