Importantly, comparison of ScAT and AAT from OA versus RA patients revealed that rheumatoid tissues are characterized by higher reactivity to pro-inflammatory IL-1β, at least in the case of CCL2/MCP-1 and MMP-3 secretion (Table 4), giving support to critical role of this stimulus in RA pathology. The gene discussed is CCL2; the disease is rheumatoid arthritis.