EPO and pure red-cell aplasia: An often cited incident occurred in 1998 for the cases of Epoetin-associated Pure red cell aplasia (PRCA) in renal failure patients, where the change in the formulation from Human Serum Albumin to polysorbate 80, subcutaneous administration and uncoated robber stoppers have been involved with the presence of anti-drug and neutralizing endogenous erythropoietin antibodies (14).