The third functionality is a cyclic neuropeptide somatostatin (SST), binding to somatostatin cell membrane receptors (SSTR) that are overexpressed at the surface of various tumor cells and SST-mediated binding induces translocation into the cytosol.17 Thiolated SST (SST-SH) with preserved circular structure and SSTR binding activity, was obtained by re-bridging the disulfide bond with a linker molecule possessing a thiol group following a published protocol.18 SST-SH was reacted with the maleimide-ssDNA* to form SST-ssDNA* (Fig. 1g). This evidence concerns the gene SST and neoplasm.