REST and Huntington disease: For example, in contrast to the proposed neurotoxicity of elevated nuclear REST in ischemia (Noh et al., 2012) and Huntington’s disease (Zuccato et al., 2003; Buckley et al., 2010), Lu et al. recently reported decreased nuclear REST in Alzheimer’s disease and neuroprotection of REST in aging brain (Lu et al., 2014).