In their paper describing altered nuclear REST in aging and AD brain, Lu et al. claimed that REST4 mRNA (N3c) level in brain tissues comprised only 0.1–0.5% of REST mRNA (Lu et al., 2014), while a number of neuronal splice variants produced by ΔE2, ΔE3, and ΔE4 (or inclusion of E5; Chen and Miller, 2013), of which ΔE3 eliminates a motif critical for nuclear targeting (Shimojo et al., 2001; Shimojo, 2006) and therefore affects nuclear REST (Chen et al., 2017) were not mentioned. The gene discussed is REST; the disease is Alzheimer disease.