Specific immunodeficiencies that place children at higher risk for viral sepsis include NK cell deficiency, interferon (IFN)-γ receptor deficiency, TLR-3 deficiency, nuclear factor-kappa B essential modulator deficiency, severe combined immunodeficiency, severe T-cell lymphopenia in DiGeorge syndrome, agammaglobulinemia, and hyperIgM syndrome (71). Here, TLR3 is linked to hyperinsulinemic hypoglycemia, familial, 4.