PTEN and posterior cortical atrophy: Among the most frequent biomarkers studied that are associated with PCa are p53 (tumor protein p53), Ki-67 (marker of proliferation), ERG (ETS-related gene), MYC (proto-oncogene), and PTEN (phosphatase and tensin homolog), which are implicated in the control of cell proliferation and differentiation, angiogenesis, and apoptosis (15–25).