IRAK1/4 inh significantly reduced renal injury in the B6.lpr model; IRAK1 is overexpressed in PBMCs from pts with SLE, and levels of NF-κB phosphorylation were reduced by IRAK1/4 inh I or IRAK1 siRNA. This evidence concerns the gene NFKB1 and systemic lupus erythematosus.