Long-term (3.7 year) follow-up of the randomized phase 3 CANTOS trial of the anti-IL-1β antibody canakinumab in patients with atherosclerosis, prior MI, and high CRP level found a 77% reduction in risk of LC death relative to placebo in the canakinumab arm (HR 0.23; P = 0.0002) [155]. The gene discussed is IL1B; the disease is atherosclerosis.