IL-17 is a critical effector molecule in GVHD [99, 100], and suppression of IL-17 and Th-17 cells by IRAK1 inhibitors, while also reducing IL-1β and IL-6 levels, suggests IRAK1 inhibition as a rational approach to treating this condition if corticosteroids fail to control the disease. Here, IRAK1 is linked to graft versus host disease.