IRAK1 and systemic lupus erythematosus: The authors postulate that patients with SLE treated with IRAK inhibitors could have less risk of severe viral infections than those treated with the current standard, anti-interferon (IFN) therapy, and that selective IRAK1 inhibition may provide a reduced risk of microbial infections relative to treatment with IRAK4 or dual IRAK1/4 inhibitors.