A recent study reported that IRAK1 was overexpressed and hyperactivated in peripheral blood mononuclear cells (PBMCs) from patients with SLE and found that IRAK1/4 inhibitor I significantly mitigated inflammatory response and renal injury in the B6.lpr mouse model of SLE, which overexpresses IRAK1 in splenic monocytes [48]. This evidence concerns the gene IRAK1 and systemic lupus erythematosus.