IRAK1 and myelodysplastic syndrome: IRAK1 overexpressed in 20–30% of patients, hyperactivated in BM samples in the majority of patients; IRAK1 expression correlates with poor survival (P = 0.035); IRAK1/4 inhibitor I is antiproliferative in MDS progenitor cells, ameliorates disease in MDS xenograft mouse model.