Hypoxia-inducible factor 1 alpha (HIF1α) is a transcription factor that is normally degraded by the proteasome via hydroxylation by prolyl hydroxylases under normoxic conditions, but is stabilized under hypoxic conditions to direct transcription of genes containing pro-survival hypoxic response elements including VEGF, which is needed to promote tumor-associated neoangiogenesis [38]. Here, HIF1A is linked to neoplasm.