We also showed that capn2 knockdown in a mouse mammary carcinoma cell line was associated with reduced tumor growth in a mouse orthotopic engraftment model [9], and capns1 knockdown in the MDA-MB-231 triple negative breast cancer cell line correlated with reduced tumor growth and metastasis in a mouse orthotopic xenograft model, and this effect was enhanced by combination with the HSP90 inhibitor, 17-AAG [25]. This evidence concerns the gene CAPN2 and breast carcinoma.