In vitro migration and invasion were both compromised by capns1 KO in mouse embryonic fibroblasts [15, 17] or capns1 knockdown in MDA-MB-231 breast cancer cells [25]; and capn2 knockdown was associated with dysregulated focal adhesion turnover [18] and lamellipodia dynamics [16] in fibroblasts, as well as attenuated migration and invasion in mammary carcinoma cells [9]. Here, CAPN2 is linked to breast carcinoma.