The HMGB1 protein regulates diverse cell functions, and its overexpression could be a hallmark of cancer, others of which include unlimited replicative potential, angiogenesis, evasion of programmed cell death (apoptosis), self-sufficiency in growth signals, insensitivity to inhibitors of growth, inflammation, tissue invasion and metastasis [7, 26–28]. This evidence concerns the gene HMGB1 and cancer.