GADD45B and chronic myelogenous leukemia, BCR-ABL1 positive: As shown in Figure 2B, survival of recipient mice that were transplanted with MIG-BCR-ABL Gadd45b-/- myeloid progenitors was significantly curtailed compared to mice transplanted with MIG-BCR-ABL wild-type progenitors, due to accelerated development of CML like disease, as manifested by increased WBC (Figure 2C), increased liver weight (Figure 2D), and increase in GFP + cells in the bone marrow and spleen (Figure 2E).