HMCN1 and breast carcinoma: We found that the Polyphen-2 score of nonsynonymous HMCN1 mutations did not significantly associate with breast cancer prognosis (PolyPhen-2 scores of < 0.85 vs. WT; P = 0.801 and PolyPhen-2 scores of ≥ 0.85 vs WT; P = 0.671) (Supplementary Figure 6).