More recently, we generated PG4D2, a neutralizing antibody recognizing the PLAG4 domain in human podoplanin and found that it strongly suppressed podoplanin–CLEC-2 binding and podoplanin-mediated hematogenous metastasis of human podoplanin-expressing tumor cells inoculated into mice [14]. The gene discussed is PDPN; the disease is neoplasm.