DNMT1 and graft versus host disease: Further, there is some indication that such anti-inflammatory effects of these drugs could translate to human disease, as patients with acute myeloid leukemia who were treated with a DNMT inhibitor after allogeneic stem cell transplantation were shown to have increased numbers of regulatory T cells, which was associated with a low incidence of graft-versus-host disease (Goodyear et al., 2012).