This result was different from the previous studies, in which decreased serum adiponectin is significantly involved in the development of colorectal adenoma.(28,30,31,55) On the other hand, some studies have shown that no association between adiponectin levels and colorectal adenoma were found.(57,58) Taking the findings of these reports and the present findings into consideration, data regarding the effect of the biomarkers on AP development may be contradictory and difficult to interpret.(25,57). The gene discussed is ADIPOQ; the disease is alkaline phosphatase measurement.