For example, Clostridium butyricum inhibited liver injury induced by carbon tetrachloride (CCl4) via nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activation.(19) In contrast, many types of cancer cells have a mechanism for Nrf2 stabilization; cancer patients showing Nrf2 stabilization have a poor prognosis.(20) In this study, we fed mice with a steatohepatitis-inducing HFD (STHD-01) diet containing various types of fatty acids and cholesterol. Here, NFE2L2 is linked to cancer.