MTOR and myocardial ischemia: Expression of survivin was induced in the myocardial infarction13, and heart failure15 in both rat and human, and also contributed to cardioprotection of insulin against myocardial ischemia/reperfusion (MI/R) injury16 or doxorubicin toxicity through the phophatidylinositide-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway17.