Here we found that the variants have been reported in Educational attainment42 (ARFGEF2), Obesity-related traits44 (PCSK2, ARFGEF2), Subjective Well-being34 (ARFGEF2, CSE1L) and height43 (STAU1, ZFAS1) (Supplementary Table 12). The gene discussed is CSE1L; the disease is obesity due to melanocortin 4 receptor deficiency.