Three additional VUS were identified in the proband: p.Leu618Phe (L618F) in the cardiac sodium channel (SCN5A, NM_198056, c.1852C > T) with an overall MAF of 0.057%, and two variants in desmosomal proteins known to be associated with ARVC: p.Asn1865Trp (N1865W) in desmoplakin (DSP, NM_004415.2, c.5593 A > T), with a frequency of 0.051%, and p.Val842Ile (V842I) in plakophilin 2 (PKP2, NM_004572, c.2524 G > A), with an MAF of 0.0049% (Supplementary Fig. S3). Here, PKP2 is linked to arrhythmogenic right ventricular cardiomyopathy.