Two cell populations are present in LAM lesions: the myofibroblastic-like cells that express markers of smooth muscle cells and fibroblasts, such as α-smooth muscle actin (α-SMA), vimentin and desmin4,5 and the epithelioid-like cells that express melanocytic markers such as MLANA (Melan A) and proteins evidenced with HMB45 and PNL2 antibodies5,6. Here, MLANA is linked to lymphangioleiomyomatosis.