Collectively, compared with controls (1.1%), GRN missense variants were seen significantly in excess in patients (3.6%, p = 0.004, OR 3.4 (1.4–8.4)) with AD (3.5%, p = 0.006, OR = 3.3) and FTD (3.7%, p = 0.006, OR = 3.4) but not DemMot (2.5%, p = 0.1, OR = 2.3) or prion disease (2.7%, p = 0.2, OR = 2.5). Here, GRN is linked to Alzheimer disease.