TRPV1 and asthma: As LPA has garnered attention as an important biomarker of the immune response in the murine house dust mite model of asthma and is present in human bronchiolar lavage fluid and venous samples following asthmatic challenge37, we hypothesize that LPA released from the asthmatic lung in response to allergen/bradykinin challenge activates TRPV1 in the carotid body causing acute bronchoconstriction.