As it was indicated above, the EGFR variant EGFRvIII is frequently observed in glioblastoma, particularly in “classic” molecular subtype of glioblastoma in conjunction with PTEN mutations; a peculiar finding of the tumors bearing EGFRvIII is related to the typical expression pattern of EGFRvIII, limited only either to sporadic cells or focal areas of positive cells. Here, EGFR is linked to glioblastoma.