The analysis of IDH-WT tumors showed the existence of three DNA methylation subgroups: two of these subgroups resemble the previously described subgroups “classic-like” and “mesenchymal-like”, while the third group can be further subdivided into two subgroups, the LGm6-GBM associated subgroup is with poor prognosis and the another, with a genomic profile similar to pilocytic astrocytoma, is associated with a good prognosis [106]. The gene discussed is IDH2; the disease is glioblastoma.