However, recent studies have provided clear evidence that IDH-WT glioblastomas can be stratified into three prognostically different groups according to copy number alterations limited to few foci (gain of whole chromosome 1, gain of whole chromosome 19, co-amplification of CDK4 and MDMD2): W1 (worst survival); W2 (intermediate survival); W3 (best survival) [393]. The gene discussed is CDK4; the disease is glioblastoma.