As discussed above, RTK genes are frequently altered in glioblastomas; in fact, at least one RTK is altered in 65–75% of glioblastomas (EGFR (50–58%), PDGFRA (12–15%), MET (2–3%), and FGFR2/3 (3%)). The gene discussed is FGFR2; the disease is glioblastoma.