The SVZ is a frequent and consequential site of pediatric and adult glioma spread, not only because represents the site of origin of NSCs, but also because glioma progenitor cells have the propensity to colonize SVZ for the secretion in this site of chemoattractants and, particularly, of the neurite outgrowth-promoting factor pleiotrophin [314]. This evidence concerns the gene PTN and glioma.