TP53 and central nervous system cancer: Some genetic models have further supported the neural stem cell origin of these tumors; thus, the inactivation of the tumor suppressor genes p53 and Neurofibromatosis (NF1) or the expression of mutant p53 in neural stem cells led to formation of glioma in mouse models, and these tumors appear to be located at the level of the subventricular zone, where adult neural stem cells are located [303,304,305].