Using a bioinformatics tool, Shatterproof, evidence was provided that glioblastoma chromotripsis is associated with the formation of amplicons containing several oncogenes receptor tyrosine kinase (RTKs), modulators of the TP53 and RB1 pathways, that are essential for postchromotriptic cell survival [4]. The gene discussed is NTRK1; the disease is glioblastoma.