Finally, a recent extensive analysis of genetic abnormalities present in medulloblastomas allowed the identification, in addition to the alterations in Hedgehog and WNT pathways, of inactivating mutations of the histone-lysine N-methyltransferase genes MLL2 or MLL3 were identified in 16% of medulloblastoma patients [165]. This evidence concerns the gene KMT2D and medulloblastoma.