Thus, they have identified a mean of 33 mutations in the initial tumor, of which an average of 54% was conserved in tumors at recurrence (the shared mutations typically involve IDH1, TP53, and ATRX); all other mutations were observed only in the original or in the recurrent tumor: those occurring in the recurrent tumors seemingly arose later during tumor development [39]. This evidence concerns the gene ATRX and neoplasm.