Interestingly, two genes involved in cytoskeleton and cell shape are downregulated by DHO-specific mutations and represent useful biomarkers: Glial Fibrillary Acidic Protein (GFAP), an astrocytic biomarker more highly expressed in IDH-A than in IDH-O gliomas and RhoC Guanosine Triphosphate (RHOC) [111]. The gene discussed is IDH2; the disease is glioma.