BDNF and central nervous system cancer: Wang et al. have investigated the reciprocal signaling between glioblastoma stem cells and their differentiated cell progeny, providing evidence that differentiated cells promote glioblastoma hierarchy through a paracrine growth loop mediated by neurotrophin signaling in cooperation with glioblastoma/stem progenitor cells: particularly, differentiated tumor cells secrete brain-derived neurotrophic factor, interacting with the receptor NTRK2 expressed on glioma stem cells [322].