In the non-NF2 meningiomas it was observed the frequent mutation of TRAF7, a proapoptotic ubiquitin ligase; a part of these meningiomas with mutated TRAF7 exhibited also KLF4 (a transcription factor involved in pluripotency) and AKT1 mutations [204] (Figure 10). This evidence concerns the gene AKT1 and meningioma.