ATRX and glioblastoma: At the level of frequent gene mutations, hemispheric H3.3G34R/V tumors are associated with TP53/ATRX mutations (90%), midline H3.3K27M with FGFR1 mutations (20.5%), pontine H3.1K27M with ACVR1 mutations (84.8%), and PXA-like glioblastomas with BRAFV600E (60.7%) [70].