MYCN and Mobius syndrome: Interestingly, remarkable transcriptional differences between MYC-dependent and MYCN-dependent MBs were observed, in part, depending on the selective capacity of MYC, but not MYCN, to interact with Myc-interacting Zinc (MIZ): the MYC–MIZ1 interaction determines the combination with chromatin binding sites [173], determining suppression of ciliogenesis, and activation of a gene repression program required for the maintenance of stemness [173].