IL13RA2 and central nervous system cancer: Studies in glioma experimental models in immunocompetent mice have provided evidence that adoptive transfer of IL13Rα2-specific CAR T cells creates a pro-inflammatory glioma microenvironment by inducing a significant increase of CD4+ and CD8+ T cells and CD8α+ dendritic cells and a decrease of Ly6t+ myeloid suppressor cells [385].