In fact, Halliday et al. have investigated in detail the sensitivity of glioblastoma proneural cells obtained in a mouse model based on PDGFRA expression in mice harboring somatic deletion of INK4A. The study of this model indicated that the response to ionizing radiations occurred primarily at the level of transcription and mainly involved genes related to apoptosis and cell growth: p53 and E2F were mainly regulators of the radiation response [338]. This evidence concerns the gene TP53 and glioblastoma.