PTEN and neoplasm: This analysis demonstrated that (a) different glioblastoma subtypes are present within the same tumor; (b) the analysis of the intratumor heterogeneity of these tumors allowed a reconstruction of the phylogeny of the tumor fragments for each patient, identifying copy number alterations in EGFR and CDKN2A/B/p14ARF as early events, and aberrations in PDGFRA and PTEN as later events during cancer progression; and (c) the analysis of individual tumor cells showed the coexistence of multiple genetic abnormalities [37].