Thus, it was shown that in both glioma initiating cells and in endothelial cells, PDGF-driven activation of nitric oxide (NO) synthase induces an increase of NO-dependent ID4 (inhibitor of differentiation 4) expression, which in turn promotes JAGGED1-NOTCH activity through suppression of miR129, specifically repressing JAGGED1 suppression [300]. Here, JAG1 is linked to central nervous system cancer.