Particularly, medulloblastoma peptide phosphorylation profiling showed two phosphoprotein-signaling profiles: the first, protein-signaling profiling that was reminiscent of the signaling that could be induced by the MYC oncoprotein, in the absence of MYC aberrancies and associated with rapid death post-recurrence (most of Group 3 tumors correspond to this group and were termed 3A); the second profile displayed increased neuronal, apoptotic, and DNA-damage signaling (most of Group 4 tumors correspond to this group and were termed 4B) [415]. Here, MYC is linked to medulloblastoma.