EGFR and glioblastoma: Cimino et al. screened 36 primary glioblastomas and observed mutations in EGFR in 10 of these tumors: five of these mutations occurred at the level of amino acid 289 (4 A289D, 1 A289T); in addition to mutations, EGFR amplification, insertions or deletions, and EGFRvIII and EGFRiiV variants were observed, showing at least one EGFR mutation in 62% of samples [47].