ACACA and fatty liver disease: Recent studies have begun to explore zebrafish homologues of mammalian genes involved in lipid metabolism; for example, several transgenic and mutant zebrafish models with hepatic steatosis exhibit elevated expression of important lipogenic genes, such as cebpa, pparg, srebp1, and acetyl-CoA carboxylase 1 (acc1), which show a similar mechanism to that observed in human hepatic steatosis [43].