LYPD8 and colitis: The whisper phenotype originally mapped to three putative ENU-introduced mutations in Myo1d, Ksr1 and Lypd8. Both Ksr1 and Lypd8 knockout (KO) mice are known to be susceptible to DSS-induced colitis (Goettel et al., 2011; Okumura et al., 2016).