ITGB1 and hepatocellular carcinoma: In our study, linc-ITGB1 overexpression significantly up-regulated the expression of ROCK1 in cells of two HCC cell lines, and ROCK1 inhibitor treatment reduced the enhancing effects of ROCK1 overexpression on HCC cell proliferation, migration, and invasion, suggesting that linc-ITGB1 may activate ROCK1 to promote HCC growth and metastasis.