Tumor exosome miRNA uptake affected the premetastatic organ stroma cells, supporting tumor cell hosting.[73] Compared with previous studies, the present study found several novel serum exosomal-miRNAs as well as several novel genes, including SH3TC2, GRIA2, PHACTR2, NTS, and CDH2, which yielded clues indicating that there are 3 target genes, NTS, CDH2, and GRIA2, that were highly correlated with the apoptosis process of PC. Here, PHACTR2 is linked to pachyonychia congenita.