An early study suggested that abnormal changes of thyroid function and serum levels of TSH are thought to be evidence of the pathogenesis of BPH.[6] In another study, Eldhose et al demonstrated the association between prostate size and TH content and found T3 content to be positively correlated with prostate size, whereas TSH content was negatively correlated with prostate size. This evidence concerns the gene TH and benign prostatic hyperplasia.