In a Japanese population, Taniguchi Y et al. found an odds ratio of 2.06 (95% CI: 1.14–3.77; p < 0.05) for cognitive decline in the lowest tertiles of serum albumin (less than 4.1 g/dL) and they suggested that low nutritional status might have a negative impact on cognitive function [23]. This evidence concerns the gene ALB and Mental deterioration.