PODXL and colorectal carcinoma: The possible reason is that the LEA/PODXL epitope recognized by 3D3 was covered by glycocalyx due to its highly glycosylated modification.53 Further evaluation of LEA expression recognized by ND‐1 in CRC tissues by IHC also revealed higher imaging signal than that by 3D3, especially in metastatic tissues (Figure 5A a2).