HIF1A and acute kidney injury: Hypoxia-inducible factor 1 (HIF-1α) is a central mediator of cellular adaptation to hypoxia and plays a pivotal role in the pathogenesis of AKI [13].Interestingly, the reciprocal regulation of HIF-1α and NF-κB has been shown, which further complicates our understanding of the underlining mechanism of AKI [14].