In fact, in melanoma cells the MAPK pathway has assumed control over the function and expression of MITF, the master transcriptional regulator of genes that not only define the melanocytic lineage, but also drive cell cycle progression and survival (Kundu, Quirit, Khouri, & Firestone, 2017; Wellbrock & Arozarena, 2015; Wellbrock et al., 2008). This evidence concerns the gene MITF and melanoma.