BRAF and melanoma: At transcriptional level BRAF induces expression from a proximal region within the MITF promoter through BRN2, a POU domain transcription factor which positively regulates MITF expression in many melanoma cell lines (Cook, Smith, Smit, Leonard, & Sturm, 2005; Kundu et al., 2017; Simmons, Pierce, Al‐Ejeh, & Boyle, 2017; Thurber et al., 2011; Wellbrock et al., 2008).