IL1B and synovitis: The purpose of this program of research was to seek insights into what effects CS/HA/pIL-1Ra nanoparticles have on synovitis induced by IL-1β in vitro, In our future research, we will observe the changes in chondrocytes phenotype when co-cultured with OA synoviocytes that pre-administrated with CS/HA/pIL-1Ra nanoparticles.