MAPT and Alzheimer disease: To extend our findings to different brain regions, we studied tau filaments from temporal, occipital, parietal, and cingulate cortices, as well as from thalamus, substantia innominata, and putamen of case 1 of sporadic AD, whose frontal cortex was used for cryo-EM and immuno-EM (Figs. 2, 4, Online Resource 7).