In this respect, a major role is played by the alteration of the Nrf2/ARE pathway, with more efficient activation of the system as “self-defense” mechanism of tumor cells and metabolic reprogramming (Iida et al. 2004; Krajka-Kuzniak et al. 2016; Sporn and Liby 2012; Taguchi and Yamamoto 2017). Here, NFE2L2 is linked to neoplasm.