In the setting of ascending aortic aneurysms, we characterized vasa vasorum remodeling by a depletion of small vessels (≤ 50 μm) with an associated decrease in the pro-angiogenic factors Hif-1α and Vegf-A gene expression and increased levels of the antiangiogenic factor TSP1, together pointing to decreased angiogenic capacity. This evidence concerns the gene THBS1 and Ascending tubular aorta aneurysm.