In gallbladder cancer tissues, the amount of the long form of APE1 (37 kDa) was significantly higher when compared with normal gallbladder (P = 0.008) and chronic cholecystitis (P= 0.03) (Fig 1.B) while the relative expression level of the short form (35 kDa) was not significantly different in cancer tissues from the other two (Fig 1.C). Here, APEX1 is linked to gallbladder cancer.