Statistical analysis using Kruskal-Wallis test (non-parametric) for comparison of YKL-40, NLR and PC with respect to tumor-grade was found to be significant for YKL-40 (P < 0.0001), NLR (P < 0.0001), and PC (P <0.0001) (Fig.1) indicating changes in plasma levels with respect to tumor grade when compared with healthy controls. The gene discussed is CHI3L1; the disease is neoplasm.