Besides inflammation, an altered endocannabinoid system tone is involved in the pathogenesis of obesity.12 Endocannabinoids exert their physiological functions in the body mainly via two receptors: cannabinoid receptors 1 and 2 (CB1 amd CB2).13 Some endocannabinoids-like compounds including oleoylethanolamide (OEA) are structurally similar to endocannabinoids but are incapable of binding to cannabinoid receptors.14 Here, CNR1 is linked to obesity due to melanocortin 4 receptor deficiency.